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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Topamax and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Topamax and M1, respectively.
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Topamax is well absorbed orally with an absolute bioavailability of 75%. Topamax has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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