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Nexium is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
Forty patients were treated with either Nexium suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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the rates of withdrawals due to adverse events appeared to be higher in the Nexium groups.
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The analgesic activity of Nexium is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Nexium and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Nexium and M1, respectively.
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Nexium group.
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