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Methotrexate was not mutagenic in the following assays: Ames Salmonella microsomal activation test,
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Methotrexate is administered as a racemate and both [-] and [+] forms of both Methotrexate and M1 are detected in the circulation.
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Methotrexate is a centrally acting synthetic opioid analgesic.

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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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Methotrexate is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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Although Methotrexate is known to exhibit a local anaesthetic effect, how Methotrexate exerts this effect is not understood fully.
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Methotrexate group.
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Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
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A single i.m. dose of Methotrexate is useful pre-treatment to minimize the risk of acid aspiration during operation,
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
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Methotrexate was not mutagenic in the following assays:
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Methotrexate may rarely be habit forming. Methotrexate should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.

In vitro studies indicate that Methotrexate is unlikely to inhibit,
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Breast-feeding�Methotrexate passes into breast milk and may cause unwanted effects in nursing babies.
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Some people who use Methotrexate for a long time without a break may develop a physical need to continue taking it.
The effects of Methotrexate and its metabolite mono-O-demethyl-Methotrexate,
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Methotrexate is rapidly and almost completely absorbed after oral administration.
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